miRNA description for miR-21-5P
miRNA accession	miR-21-5P
Species	Homo sapiens
miR-21-5P identified in exosomes derived from the following tissue/cell type
Adipose-derived mesenchymal stem cells [Exosomes]	28170197
Bone marrow mesenchymal stem cells [Exosomes]	28170197
Colorectal cancer cells [Exosomes]	29472616
Colorectal cancer cells [Exosomes]	29472616
Colorectal cancer cells [Exosomes]	29472616
Endometrium-derived mesenchymal stem cells [Exosomes]	28170197
Lung cancer cells [Small extracellular vesicles]	34596365
Lung cancer cells [Small extracellular vesicles]	34596365
Lung cancer cells [Small extracellular vesicles]	34596365
Lung cancer cells [Small extracellular vesicles]	34596365
Mesenchymal stem cells [Exosomes]	33479185
Mesenchymal stem cells [Extracellular vesicles]	34596354
Platelets [Platelet-derived microparticles]	33009394
Platelets [Platelet-derived microparticles]	33009394
Platelets [Platelet-derived microparticles]	33009394
Platelets [Platelet-derived microparticles]	33009394
Platelets [Platelet-derived microparticles]	33009394
Platelets [Platelet-derived microparticles]	33009394
Posterior longitudinal ligament [Small extracellular vesicles]	35513391
Posterior longitudinal ligament [Small extracellular vesicles]	35513391
Serum [Extracellular vesicles]	29887978
Urine [Exosomes]	24352158
Experiment description of studies that identified miR-21-5P in exosomes
1 Experiment ID 689 Identified molecule miRNA Identification method Microarray qRT-PCR PubMed ID 28170197    Organism Homo sapiens Experiment description Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21 Authors Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li Q, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J. Journal name Stem Cells Transl Med Publication year 2017 Sample Adipose-derived mesenchymal stem cells Sample name AdMSC'S Molecules identified in the study miRNA Methods used in the study Microarray qRT-PCR EV-TRACK -
2 Experiment ID 690 Identified molecule miRNA Identification method Microarray qRT-PCR PubMed ID 28170197    Organism Homo sapiens Experiment description Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21 Authors Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li Q, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J. Journal name Stem Cells Transl Med Publication year 2017 Sample Bone marrow mesenchymal stem cells Sample name BMMSC's Molecules identified in the study miRNA Methods used in the study Microarray qRT-PCR EV-TRACK -
3 Experiment ID 1435 Identified molecule miRNA Identification method miR-chip array PubMed ID 29472616    Organism Homo sapiens Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 Authors Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC. Journal name Nat Commun Publication year 2018 Sample Colorectal cancer cells Sample name HCT116 Molecules identified in the study Protein miRNA Methods used in the study Western blotting miR-chip array EV-TRACK -
4 Experiment ID 1436 Identified molecule miRNA Identification method miR-chip array PubMed ID 29472616    Organism Homo sapiens Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 Authors Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC. Journal name Nat Commun Publication year 2018 Sample Colorectal cancer cells Sample name HCT116 Molecules identified in the study Protein miRNA Methods used in the study Western blotting miR-chip array EV-TRACK -
5 Experiment ID 1437 Identified molecule miRNA Identification method miR-chip array PubMed ID 29472616    Organism Homo sapiens Experiment description Mutant p53 cancers reprogram macrophages to tumor supporting macrophages via exosomal miR-1246 Authors Cooks T, Pateras IS, Jenkins LM, Patel KM, Robles AI, Morris J, Forshew T, Appella E, Gorgoulis VG, Harris CC. Journal name Nat Commun Publication year 2018 Sample Colorectal cancer cells Sample name HCT116 Molecules identified in the study Protein miRNA Methods used in the study Western blotting miR-chip array EV-TRACK -
6 Experiment ID 688 Identified molecule miRNA Identification method Microarray qRT-PCR PubMed ID 28170197    Organism Homo sapiens Experiment description Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21 Authors Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li Q, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J. Journal name Stem Cells Transl Med Publication year 2017 Sample Endometrium-derived mesenchymal stem cells Sample name EnMSC's Molecules identified in the study miRNA Methods used in the study Microarray qRT-PCR EV-TRACK -
7 Experiment ID 3224 Identified molecule miRNA Identification method RT-qPCR PubMed ID 34596365    Organism Homo sapiens Experiment description Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer Authors Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ. Journal name J Extracell Vesicles Publication year 2021 Sample Lung cancer cells Sample name A549 Molecules identified in the study miRNA Methods used in the study RT-qPCR EV-TRACK -
8 Experiment ID 3225 Identified molecule miRNA Identification method RT-qPCR PubMed ID 34596365    Organism Homo sapiens Experiment description Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer Authors Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ. Journal name J Extracell Vesicles Publication year 2021 Sample Lung cancer cells Sample name A549 Molecules identified in the study miRNA Methods used in the study RT-qPCR EV-TRACK -
9 Experiment ID 3226 Identified molecule miRNA Identification method RT-qPCR PubMed ID 34596365    Organism Homo sapiens Experiment description Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer Authors Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ. Journal name J Extracell Vesicles Publication year 2021 Sample Lung cancer cells Sample name 2106T Molecules identified in the study miRNA Methods used in the study RT-qPCR EV-TRACK -
10 Experiment ID 3227 Identified molecule miRNA Identification method RT-qPCR PubMed ID 34596365    Organism Homo sapiens Experiment description Small extracellular vesicle-derived miR-574-5p regulates PGE2-biosynthesis via TLR7/8 in lung cancer Authors Donzelli J, Proestler E, Riedel A, Nevermann S, Hertel B, Guenther A, Gattenlöhner S, Savai R, Larsson K, Saul MJ. Journal name J Extracell Vesicles Publication year 2021 Sample Lung cancer cells Sample name 2106T Molecules identified in the study miRNA Methods used in the study RT-qPCR EV-TRACK -
11 Experiment ID 1526 Identified molecule miRNA Identification method Microarray PubMed ID 33479185    Organism Homo sapiens Experiment description Human umbilical cord mesenchymal stem cell-derived exosomal miR-146a-5p reduces microglial-mediated neuroinflammation via suppression of the IRAK1/TRAF6 signaling pathway after ischemic stroke Authors Zhang Z, Zou X, Zhang R, Xie Y, Feng Z, Li F, Han J, Sun H, Ouyang Q, Hua S, Lv B, Hua T, Liu Z, Cai Y, Zou Y, Tang Y, Jiang X. Journal name Aging Publication year 2021 Sample Mesenchymal stem cells Sample name hUMSCs Molecules identified in the study Protein miRNA Methods used in the study Western blotting Microarray EV-TRACK -
12 Experiment ID 3202 Identified molecule miRNA Identification method Small RNA sequencing PubMed ID 34596354    Organism Homo sapiens Experiment description Extracellular vesicles from adipose tissue-derived stem cells alleviate osteoporosis through osteoprotegerin and miR-21-5p Authors Lee KS, Lee J, Kim HK, Yeom SH, Woo CH, Jung YJ, Yun YE, Park SY, Han J, Kim E, Sul JH, Jung JM, Park JH, Choi JS, Cho YW, Jo DG. Journal name J Extracell Vesicles Publication year 2021 Sample Mesenchymal stem cells Sample name Adipose tissue-derived stem cells Molecules identified in the study Protein miRNA Methods used in the study Flow cytometry Small RNA sequencing ddPCR EV-TRACK -
13 Experiment ID 1344 Identified molecule miRNA Identification method qPCR PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood Molecules identified in the study Protein miRNA Methods used in the study Flow cytometry Western blotting qPCR EV-TRACK -
14 Experiment ID 1346 Identified molecule miRNA Identification method miRNA array PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood - donor 1 Molecules identified in the study miRNA Methods used in the study miRNA array EV-TRACK -
15 Experiment ID 1347 Identified molecule miRNA Identification method miRNA array PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood - donor 2 Molecules identified in the study miRNA Methods used in the study miRNA array EV-TRACK -
16 Experiment ID 1348 Identified molecule miRNA Identification method miRNA array PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood - donor 3 Molecules identified in the study miRNA Methods used in the study miRNA array EV-TRACK -
17 Experiment ID 1349 Identified molecule miRNA Identification method miRNA array PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood - donor 4 Molecules identified in the study miRNA Methods used in the study miRNA array EV-TRACK -
18 Experiment ID 1350 Identified molecule miRNA Identification method miRNA array PubMed ID 33009394    Organism Homo sapiens Experiment description Platelet-derived microparticles enhance megakaryocyte differentiation and platelet generation via miR-1915-3p Authors Qu M, Zou X, Fang F, Wang S, Xu L, Zeng Q, Fan Z, Chen L, Yue W, Xie X, Pei X. Journal name Nat Commun Publication year 2020 Sample Platelets Sample name Platelets derived from umbilical cord blood - donor 5 Molecules identified in the study miRNA Methods used in the study miRNA array EV-TRACK -
19 Experiment ID 2739 Identified molecule miRNA Identification method RNA sequencing PubMed ID 35513391    Organism Homo sapiens Experiment description Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1 Authors Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L, Hu B, Zhang H, Shen X, Wang Y, Liu Y, Yuan W. Journal name Nat Commun Publication year 2022 Sample Posterior longitudinal ligament Sample name Ossicifation of posterior longitudinal ligament cells Molecules identified in the study Protein miRNA Methods used in the study Western blotting RNA sequencing qRT-PCR EV-TRACK -
20 Experiment ID 2740 Identified molecule miRNA Identification method RNA sequencing PubMed ID 35513391    Organism Homo sapiens Experiment description Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1 Authors Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L, Hu B, Zhang H, Shen X, Wang Y, Liu Y, Yuan W. Journal name Nat Commun Publication year 2022 Sample Posterior longitudinal ligament Sample name Posterior longitudinal ligament cells Molecules identified in the study miRNA Methods used in the study RNA sequencing qRT-PCR EV-TRACK -
21 Experiment ID 1038 Identified molecule miRNA Identification method Next generation sequencing PubMed ID 29887978    Organism Homo sapiens Experiment description Evaluation of serum extracellular vesicle isolation methods for profiling miRNAs by next-generation sequencing. Authors Buschmann D, Kirchner B, Hermann S, Mäe M, Wurmser C, Brandes F, Kotschote S, Bonin M, Steinlein OK, Pfaffl MW, Schelling G, Reithmair M. Journal name J Extracell Vesicles. Publication year 2018 Sample Serum Sample name Serum - Sepsis patient (miRCURY) Molecules identified in the study Protein miRNA Methods used in the study Western blotting Next generation sequencing EV-TRACK -
22 Experiment ID 357 Identified molecule miRNA Identification method RNA deep sequencing PubMed ID 24352158    Organism Homo sapiens Experiment description Characterization and deep sequencing analysis of exosomal miRNA in human urine Authors Lesley Cheng, Xin Sun, Bradley M. Coleman, Andrew F. Hill Journal name Kidney Int Publication year 2014 Sample Urine Sample name Urine - Normal Molecules identified in the study miRNA Methods used in the study RNA deep sequencing EV-TRACK EV140147: EV-METRIC:44%, 0%, 22%